The i-75 in Florida runs mostly in a north-south direction along the western coast of Florida (passing through the metropolis of Tampa), however, near the south-western section of the i-75 (around Naples) , the Interstate Highway turns east and travels across the southern portion of Florida (through/across the Everglades) in a east-west direction to the east coast of Florida where it connects to the the greater Miami area.

The i-75 connects most of the larger cities located along the western portion of Florida state, some of the cites/communities located along or near the i-75 corridor in Florida include; Alachua, Bradenton, Brandon, Cape Coral, Fort Myers, Gainesville, High Springs, Lake City, Naples, Ocala, Port Charlotte, Punta Gorda, Riverview, Sarasota, Sun City Center, Tampa... see a full list of cities along the i-75 corridor in Florida we currently provide real-time traffic info for.

The length of the i-75 in Florida at approximately 482 miles long, and requires a continuous driving time of approx. 7 hrs. & 32 minutes to complete.